Missy Werner grew up in a family band in the Cincinnati-Northern Kentucky area. After marrying Artie Werner in 1990, she became the lead singer and mandolin player of their band, Next In Line, which became the Missy Werner Band around 2009 when she formed a touring band after issuing her first CD, Drifting and Dreaming. Since then, the band has become one of the most popular bluegrass bands in the area. She also appears with the Comet Bluegrass All-Stars and Them There Mountain Boys.

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